Murine neuronal progenitor cells are preferentially recruited to tumor vasculature via a4-integrin and SDF-1a dependent mechanisms
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منابع مشابه
Endothelial progenitor cells are recruited into resolving venous thrombi.
BACKGROUND The purpose of this study was to determine whether endothelial cells of bone marrow origin are involved in thrombus recanalization. METHODS AND RESULTS Irradiated mice were reconstituted with bone marrow from transgenic donors expressing green fluorescent protein (GFP) linked to the Tie2 promoter. Thrombi were formed in 2 groups of 6 mice. GFP-expressing cells were located and quan...
متن کاملHuman mesenchymal stem cells are recruited to injured liver in a β1-integrin and CD44 dependent manner.
UNLABELLED Human bone marrow mesenchymal stem cells (hMSCs) have shown benefit in clinical trials of patients with liver disease. Efficient delivery of cells to target organs is critical to improving their effectiveness. This requires an understanding of the mechanisms governing cellular engraftment into the liver. Binding of hMSCs to normal/injured liver tissue, purified extracellular matrices...
متن کاملExpression of CXC Chemokines Gro/KC and SDF-1a in Rat H4 Hepatoma Cells in Response to Different Stimuli
Background: It is now well established that several environmental stress factors cause activation of p38 MAP kinase and JNK in various cell types to produce chemokines. Objective: To investigate the expression of CXC chemokines Gro/KC and SDF- 1a in rat's H4 hepatoma cells in response to heat shock, hyperosmolarity and oxidative stress. Methods: Hepatoma cells were maintained in MEM medium. Cel...
متن کاملProtective Effect of Ischemic Preconditioning via ''Imported'' Nitric Oxide Synthase Endothelial Progenitor Cells Are Rapidly Recruited to Myocardium and Mediate
Masaaki Ii, Hiromi Nishimura, Atsushi Iwakura, Andrea Wecker, Elizabeth Eaton, Takayuki Activity Protective Effect of Ischemic Preconditioning via ''Imported'' Nitric Oxide Synthase Endothelial Progenitor Cells Are Rapidly Recruited to Myocardium and Mediate Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2005 American Heart Association, Inc. All rights reserved. is published by the A...
متن کاملMonitoring functionality and morphology of vasculature recruited by factors secreted by fast-growing tumor-generating cells.
The subcutaneous matrigel plug assay in mice is a method of choice for the in vivo evaluation of pro- and anti-angiogenic factors. In this method, desired factors are introduced into cold-liquid ECM-mimic gel which, after subcutaneous injection, solidifies to form an environment mimicking the cancer milieu. This matrix permits the penetration of host cells, such as endothelial cells, and theref...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2004
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.3.9.1036